A lipophilic and non-hydrolyzable cAMP analog that acts as a site-selective inhibitor of PKA type I and II

Rp-8-CPT-Cyclic AMP (sodium salt) – 500 µg

Brand:
Cayman
CAS:
221905-35-7
Storage:
-20
UN-No:
Non-Hazardous - /

Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP (Item No. 12011) and Rp-cyclic AMPS (Item No. 16985).{26217} It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II.{26215} By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.{26215,28143}  

 

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Description

A lipophilic and non-hydrolyzable cAMP analog that acts as a site-selective inhibitor of PKA type I and II, with preference towards site A of type I and site B of type II

Formal name: ​8-[(4-chlorophenyl)thio]-adenosine cyclic 3′,5′-[hydrogen (R)-phosphorothioate]​, monosodium salt

Synonyms:  Rp-8-CPT-cAMP

Molecular weight: 509.8

CAS: 221905-35-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKA||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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