A potent thrombin inhibitor (Ki = 4.5 nM); also inhibits trypsin (Ki = 50.3 nM)

Dabigatran – 50 mg

Brand:
Cayman
CAS:
211914-51-1
Storage:
-20
UN-No:
Non-Hazardous - /

Dabigatran is a potent thrombin inhibitor (Ki = 4.5 nM).{28063,28064} It also inhibits trypsin (Ki = 50.3 nM), but only weakly inhibits other serine proteases.{28063,28064} Dabigatran has poor bioavailability after oral administration. However, dabigatran etexilate (Item No. 17131) is a double prodrug that has excellent oral bioavailability and undergoes in vivo hydrolytic cleavage to produce dabigatran.{28063,28064}  

 

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Description

A potent thrombin inhibitor (Ki = 4.5 nM); also inhibits trypsin (Ki = 50.3 nM), but only weakly inhibits other serine proteases; has poor bioavailability after oral administration

Formal name: N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine

Synonyms:  BIBR 953

Molecular weight: 471.5

CAS: 211914-51-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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