An adenosine A2B receptor agonist (EC50 = 3 nM for human A2B receptors) that displays selectivity over A1

BAY 60-6583 – 5 mg

Brand:
Cayman
CAS:
910487-58-0
Storage:
-20
UN-No:
Non-Hazardous - /

BAY 60-6583 is an adenosine A2B receptor agonist (EC50 = 3 nM for human A2B receptors) that displays selectivity over A1, A2A, and A3 receptors (EC50s = >10 µM).{27932} It has been used to decrease superoxide production in neutrophils and to study the role of the A2B receptor in regulating inflammation and mediating metabolic homeostasis in a mouse model of type 2 diabetes and obesity.{27933,27934} BAY 60-6583 has also been examined for potential clinical use in disorders of the coronary arteries and atherosclerosis and in ischemia-reperfusion injury.{27932}  

 

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Description

An adenosine A2B receptor agonist (EC50 = 3 nM for human A2B receptors) that displays selectivity over A1, A2A, and A3 receptors (EC50s = >10 µM); used to study the role of the A2B receptor in regulating inflammation and mediating metabolic homeostasis

Formal name: 2-[[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide

Synonyms: 

Molecular weight: 379.4

CAS: 910487-58-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Coronary Artery Disease||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Immunology & Inflammation

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