An inhibitor of acid ceramidase (IC50 = 79 nM); inhibits acid ceramidase activity

ARN14974 – 1 mg

Brand:
Cayman
CAS:
1644158-57-5
Storage:
-20
UN-No:
Non-Hazardous - /

ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase (IC50 = 79 nM).{27811} It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to 20 mM. In vivo, ARN14974 (10 mg/kg, i.v.) reduces acid ceramidase activity in multiple organs, including brain, liver, heart, lungs, and kidney, and increases pulmonary ceramide levels in mice.  

 

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An inhibitor of acid ceramidase (IC50 = 79 nM); inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages from 0.1-20 mM; reduces acid ceramidase activity in multiple organs and increases pulmonary ceramide levels in mice at 10 mg/kg

Formal name: 6-(4-fluorophenyl)-2-oxo-N-(4-phenylbutyl)-3(2H)-benzoxazolecarboxamide

Synonyms:  Acid Ceramidase Inhibitor 17a

Molecular weight: 404.4

CAS: 1644158-57-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Cancer||Research Area|Lipid Biochemistry|Sphingolipids

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