A depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain; effective against Gram-positive bacteria

Enopeptin A – 2.5 mg

Brand:
Cayman
CAS:
139601-96-0
Storage:
-20
UN-No:
Non-Hazardous - /

Enopeptin A, originally isolated from a culture broth of Streptomyces sp. RK-1051, is a depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain.{27772,27773} It is effective against Gram-positive bacteria, including methicillin-resistant S. aureus (MIC = 25 µg/ml), and Gram-negative bacteria, including mutant forms of E. coli and P. aeruginosa (MICs = 200 µg/ml); however, it is not inhibitory to fungi.{27772}  

 

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Description

A depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain; effective against Gram-positive bacteria, including methicillin-resistant S. aureus (MIC = 25 µg/ml), and Gram-negative bacteria, including mutant forms of E. coli and P. aeruginosa (MICs = 200 µg/ml) yet does not inhibit fungi

Formal name: (4R)-N-[(2E,4E,6E,8E,10E)-12-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-1,12-dioxo-2,4,6,8,10-dodecapentaen-1-yl]-L-phenylalanyl-L-seryl-L-prolyl-L-proline, (6→2)-lactone

Synonyms:  BRN 537924|NSC 657143

Molecular weight: 896

CAS: 139601-96-0

Purity: ≥95%

Formulation: A yellow solid

Product Type|Biochemicals|Antibiotics|Polypeptides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA

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