A selective substrate for AMPK based on the sequence around Ser79 on acetyl-CoA carboxylase

SAMS Peptide – 1 mg

Brand:
Cayman
CAS:
125911-68-4
Storage:
-20
UN-No:
Non-Hazardous - /

AMP-activated protein kinase (AMPK) plays a role in energy metabolism and glucose homeostasis by monitoring the ratio of ATP to AMP. This kinase can inactivate HMG-CoA reductase and acetyl-CoA carboxylase as well as block the activation of hormone-sensitive lipase by cyclic-AMP-dependent protein kinase (protein kinase A or PKA). SAMS peptide is a synthetic peptide substrate for AMPK based on the sequence around Ser79 (which is phosphorylated exclusively by AMPK) on acetyl-CoA carboxylase.{28356} In this sequence, Ser77 (which is phosphorylated exclusively by PKA) is replaced by alanine to eliminate a neighboring binding site for PKA.{28356} This substitution yields a substrate more specific for AMPK than acetyl-CoA carboxylase itself. SAMS peptide is phosphorylated rapidly by AMPK, providing a convenient and sensitive tool for assaying AMPK activity.{28357}  

 

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Description

A selective substrate for AMPK based on the sequence around Ser79 on acetyl-CoA carboxylase

Formal name: L-histidyl-L-methionyl-L-arginyl-L-seryl-L-alanyl-L-methionyl-L-serylglycyl-L-leucyl-L-histidyl-L-leucyl-L-valyl-L-lysyl-L-arginyl-L-arginine

Synonyms: 

Molecular weight: 1,779.20

CAS: 125911-68-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Peptides||Research Area|Endocrinology & Metabolism|Nutrient Sensing

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