A sesquiterpene lactone with anti-inflammatory effects

Helenalin – 1 mg

Brand:
Cayman
CAS:
6754-13-8
Storage:
-20
UN-No:
Non-Hazardous - /

Helenalin is a sesquiterpene lactone first isolated from various species of Arnica. It has anti-inflammatory effects, most notably by inhibiting gene expression mediated by NF-κB at doses from 1 to 20 µM.{27838,24738} Like other sesquiterpene lactones, helenalin can modify sulfhydryl groups of cysteine residues and it alkylates these groups on the p65 subunit of NF-κB.{27838} It also suppresses the proliferation of cancer cells through multiple mechanisms, including the prevention of signaling through NF-κB.{27836,20972,27837} Helenalin has antibacterial and anti-protozoal activities.{27839,27840}  

 

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Description

A sesquiterpene lactone with anti-inflammatory effects, most notably by inhibiting gene expression mediated by NF-κB at doses from 1 to 10 µM; suppresses the proliferation of cancer cells through multiple mechanisms; has antibacterial and anti-protozoal activities

Formal name: 3,3aS,4S,4aR,7aR,8R,9,9aR-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-azuleno[6,5-b]furan-2,5-dione

Synonyms:  NSC 85236

Molecular weight: 262.3

CAS: 6754-13-8

Purity: ≥98%

Formulation: A powder

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Parasitic Diseases

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