An anti-inflammatory agent that directly binds HMGB1 and HMGB2 and reduces their cytoplasmic accumulation in microglial cells; downregulates proinflammatory functions of HMGB proteins and reduces neuronal damage in vivo; ameliorates inflammatory pathogenesis in a mouse model of sepsis

Inflachromene – 5 mg

Brand:
Cayman
CAS:
908568-01-4
Storage:
-20
UN-No:
Non-Hazardous - /

Inflachromene is an anti-inflammatory agent that directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells.{27536} It is functional in vivo, downregulating proinflammatory functions of HMGB proteins and reducing neuronal damage.{27536} Inflachromene also ameliorates inflammatory pathogenesis in a mouse model of sepsis.{33796}  

 

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Description

An anti-inflammatory agent that directly binds HMGB1 and HMGB2 and reduces their cytoplasmic accumulation in microglial cells; downregulates proinflammatory functions of HMGB proteins and reduces neuronal damage in vivo; ameliorates inflammatory pathogenesis in a mouse model of sepsis

Formal name: 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-[1]benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione

Synonyms:  ICM

Molecular weight: 377.4

CAS: 908568-01-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Neuroscience

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