A cell-permeable inhibitor of MDM2 (Ki = 28 nM); promotes MDM2 auto-ubiquitination and proteasomal degradation; induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo

SP 141 – 10 mg

Brand:
Cayman
CAS:
1253491-42-7
Storage:
-20
UN-No:
Non-Hazardous - /

Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome.{11628} SP 141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM).{27642} Binding of MDM2 by SP 141 promotes its auto-ubiquitination and proteasomal degradation.{27642,29204} SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo.{27642,29204} This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.{29203}  

 

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Description

A cell-permeable inhibitor of MDM2 (Ki = 28 nM); promotes MDM2 auto-ubiquitination and proteasomal degradation; induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo

Formal name: 6-methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole

Synonyms:  AGN-PC-0D106I

Molecular weight: 324.4

CAS: 1253491-42-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis

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