A non-hydrolyzable phosphorothioate analog of cAMP that competitively inhibits cAMP-dependent protein kinases (PKA) I and II (IC50s = 12.5 and 4.5 µM

Rp-Cyclic AMPS (triethylammonium salt) – 1 mg

Brand:
Cayman
CAS:
151837-09-1
Storage:
-20
UN-No:
Non-Hazardous - /

Rp-Cyclic AMPS (Rp-cAMPS) is a non-hydrolyzable phosphorothioate analog of cAMP.{26216} It is a competitive inhibitor of cAMP-dependent protein kinases I and II (IC50s = 12.5 and 4.5 µM, respectively).{27707,27705} Rp-cAMPS is not hydrolyzed by bovine heart cAMP phosphodiesterase but can be hydrolyzed by yeast phosphodiesterase.{27706} It is broadly used in research involving cAMP-dependent signaling in vitro and in vivo.{26216,26217,26218}  

 

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Description

A non-hydrolyzable phosphorothioate analog of cAMP that competitively inhibits cAMP-dependent protein kinases (PKA) I and II (IC50s = 12.5 and 4.5 µM, respectively); broadly used in research involving cAMP-dependent signaling in vitro and in vivo

Formal name: cyclic 3′,5′-[hydrogen (R)-phosphorothioate] adenosine, triethylammonium salt

Synonyms:  Rp-cAMPS

Molecular weight: 446.5

CAS: 151837-09-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKA||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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