A CPT1 and CPT2 inhibitor that inhibits rat heart and liver CPT1 (IC50 = 77 and 148 µM

Perhexiline (maleate) – 5 mg

Brand:
Cayman
CAS:
6724-53-4
Storage:
-20
UN-No:
Non-Hazardous - /

Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s.{28039,28040,28041} It inhibits rat heart and liver CPT1 (IC50 = 77 and 148 µM, respectively) and rat heart CPT2 (IC50 = 79 µM).{28039,28040} Inhibition of CPT reduces uptake of long-chain fatty acids into the mitochondria, thereby shifting cellular metabolism from β-oxidation to glycolysis. Perhexilin inhibits mTORC1 signaling at 10 µM and induces autophagy ~7-fold at a concentration of 10 µM in MCF-7 cells.{17472}  

 

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Description

A CPT1 and CPT2 inhibitor that inhibits rat heart and liver CPT1 (IC50 = 77 and 148 µM, respectively), and rat heart CPT2 (IC50 = 79 µM); inhibits mTORC1 signaling and induces autophagy in MCF-7 cells at low µM levels

Formal name: 2-(2,2-dicyclohexylethyl)-piperidine, 2Z-butenedioate

Synonyms: 

Molecular weight: 393.6

CAS: 6724-53-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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