A lipoic acid analog that inhibits α-ketoglutarate dehydrogenase

CPI-613 – 5 mg

Brand:
Cayman
CAS:
95809-78-2
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Lipoic acid (Item No. 10005728) is a natural organosulfur compound that serves as a cofactor in various complexes, including the α-ketoglutarate dehydrogenase complex, which is involved in the citric acid cycle as well as other pathways. CPI-613 is a lipoic acid analog that inhibits α-ketoglutarate dehydrogenase, particularly in tumor cells.{27997} At 60-240 µM, CPI-613 induces a strong mitochondrial burst of reactive oxygen species, resulting in cell death.{27997} By disrupting mitochondrial metabolism, CPI-613 demonstrates both in vitro and in vivo anti-tumor activity through both apoptotic and non-apoptotic pathways.{27998,27996,27999}  

 

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Description

A lipoic acid analog that inhibits α-ketoglutarate dehydrogenase, particularly in tumor cells; induces a strong mitochondrial burst of reactive oxygen species at 60-240 µM, resulting in cell death; demonstrates both in vitro and in vivo anti-tumor activity

Formal name: 6,8-bis[(phenylmethyl)thio]-octanoic acid

Synonyms: 

Molecular weight: 388.6

CAS: 95809-78-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Metabolism||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins

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