An inhibitor of the mitochondrial pyruvate carrier; inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50 = 50 nM); decreases glucose flux to the TCA cycle and increases production of M6 citrate via glutaminolytic flux through malic enzymes in C2C12 myotubes at 10 mM; decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with BPTES and etomoxir

UK 5099 – 5 mg

Brand:
Cayman
CAS:
56396-35-1
Storage:
-20
UN-No:
Non-Hazardous - /

UK 5099 is a potent inhibitor of the mitochondrial pyruvate carrier (MPC) that inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50 = 50 nM).{28011} It decreases glucose flux to the TCA cycle and increases production of M6 citrate via glutaminolytic flux through malic enzymes without affecting ATP-linked or uncoupled oxygen consumption in C2C12 myotubes when used at a concentration of 10 mM.{47146} UK 5099 decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with BPTES (Item No. 19284) and/or etomoxir (Item No. 11969).  

 

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Description

An inhibitor of the mitochondrial pyruvate carrier; inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50 = 50 nM); decreases glucose flux to the TCA cycle and increases production of M6 citrate via glutaminolytic flux through malic enzymes in C2C12 myotubes at 10 mM; decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with BPTES and etomoxir,

Formal name: 2-cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid

Synonyms: 

Molecular weight: 288.3

CAS: 56396-35-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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