An anticancer flavonol; decreases proliferation in K562

Casticin – 5 mg

Brand:
Cayman
CAS:
479-91-4
Storage:
-20
UN-No:
Non-Hazardous - /

Casticin is a flavonol isolated from A. annua, V. trifolia, and V. agnus-castus that decreases proliferation in K562, HL-60, and Kasumi-1 leukemia cell lines (IC50s = 5.95, 4.82, and 15.56 µM, respectively).{38024} It blocks TGF-β/SMAD signaling in LX2 cells preventing activation, inhibiting proliferation, and inducing apoptosis of these hepatic stellate cells.{38025} In a mouse model of liver fibrosis, casticin (20 mg/kg) decreases TGF-β1 mRNA and phosphorylated SMAD (p-SMAD) levels. Casticin induces apoptosis in hepatocellular carcinoma (HCC) and breast cancer cells.{27628,27627} It also downregulates Twist and prevents the epithelial-mesenchymal transition (EMT) in human HCC SMMC-7721 cells.{27268}  

 

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Description

An anticancer flavonol; decreases proliferation in K562, HL-60, and Kasumi-1 leukemia cells lines (IC50s = 5.95, 4.82, and 15.56 µM, respectively); blocks TGF-β/SMAD signaling in LX2 cells; decreases TGF-β1 mRNA and p-SMAD levels in a mouse model of liver fibrosis at a dose of 20 mg/kg; downregulates Twist and prevents EMT in HCC cells

Formal name: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one

Synonyms:  Vitexicarpin

Molecular weight: 374.3

CAS: 479-91-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Transcription Factors

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