A cell-permeable inhibitor of Hhat (IC50 = 0.85 µM); blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn

RU-SKI 43 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
1782573-67-4
Storage:
-20
UN-No:
Non-Hazardous - /

Hedgehog acyltransferase (Hhat) is an N-palmitoyltransferase that acylates Sonic hedgehog (Shh), which is critical for signaling through Shh. RU-SKI 43 is an inhibitor of Hhat (IC50 = 0.85 µM).{27935} It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a.{27935} RU-SKI 43 is cell-permeable and inhibits both autocrine and paracrine Shh-induced activation of Gli-mediated transcription.{27935} In pancreatic cancer cells, RU-SKI 43 reduces both Gli1 activation and proliferation.{27936}  

 

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Description

A cell-permeable inhibitor of Hhat (IC50 = 0.85 µM); blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a; inhibits both autocrine and paracrine Shh-induced activation of Gli-mediated transcription

Formal name: 1-[6,7-dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-ethanone, monohydrochloride

Synonyms: 

Molecular weight: 423

CAS: 1782573-67-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acyltransferases||Research Area|Cancer|Cell Signaling|Hedgehog Signaling||Research Area|Cancer|Transcription Factors||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling

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