A site-specific

4-Thiouracil – 1 g

Brand:
Cayman
CAS:
591-28-6
Storage:
-20
UN-No:
Non-Hazardous - /

4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts.{29954} It absorbs ultraviolet light >300 nm and, in the presence of oxygen, acts as an energy donor to produce singlet oxygen by triplet-triplet energy transfer. The highly reactive oxygen species then reacts readily with 4-thiouracil, leading to the production of uracil and uracil-6-sulfonate, which is fluorescent at a wavelength of ~390 nm.{29955} 4-Thiouracil is used as a T. gondii uracil phosphoribosyltransferase substrate to produce 4-thiouridine monophosphate, which can ultimately be incorporated into RNA.{29956}  

 

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Description

A site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts

Formal name: 3,4-dihydro-4-thioxo-2(1H)-pyrimidinone

Synonyms:  2-hydroxy-4-Mercaptopyrimidine|4-Thiopyrimidin-2-one|4-TU|NSC 43288

Molecular weight: 128.1

CAS: 591-28-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Oxidative Stress & Reactive Species|DNA/RNA Oxidative Damage||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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