An agonist of TrkB (Kd = 320 nM) that protects TrkB-expressing neurons from apoptosis; neuroprotective in an animal model of Parkinson’s disease

7,8-Dihydroxyflavone – 500 mg

Brand:
Cayman
CAS:
38183-03-8
Storage:
-20
UN-No:
Non-Hazardous - /

7,8-Dihydroxyflavone (7,8-DHF) is a monophenolic flavone with diverse effects. It acts as an agonist of the neurotrophic tyrosine kinase receptor TrkB (Kd = 320 nM), protecting neurons that express TrkB from apoptosis.{27651} 7,8-DHF is neuroprotective in an animal model of Parkinson’s disease.{27651} It supports emotional learning in mice and reverses memory deficits in a mouse model of Alzheimer’s disease.{27655,27653} It also improves motor function and extends survival in an animal model of Huntington’s disease.{27650} 7,8-DHF inhibits the cytochrome P450 aromatase (IC50 = 10 µM) and, in this way, alters estrogen metabolism.{27652} It also has antioxidant action that increases intracellular glutathione synthesis and scavenges reactive oxygen species.{27654}  

 

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Description

An agonist of TrkB (Kd = 320 nM) that protects TrkB-expressing neurons from apoptosis; neuroprotective in an animal model of Parkinson’s disease, reverses memory deficits in a mouse model of Alzheimer’s disease, and improves motor function and extends survival in an animal model of Huntington’s disease

Formal name: 7,8-dihydroxy-2-phenyl-4H-1-benzopyran-4-one

Synonyms:  7,8-DHF

Molecular weight: 254.2

CAS: 38183-03-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Activators|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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