A cationic cholesterol derivative; as a component of lipoplexes with DOPE and mRNA

DC-Chol (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
166023-21-8
Storage:
-20
UN-No:
Non-Hazardous - /

DC-Chol is a cationic cholesterol derivative.{47233} DC-Chol, as a component of lipoplexes with DOPE (Item No. 15091), has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/DOPE liposomes or lipoplexes with human whole blood has no effect on neutrophil elastase or β-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility. DC-Chol has also been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice.{47234,47235,47236,47237}  

 

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Description

A cationic cholesterol derivative; as a component of lipoplexes with DOPE and mRNA, has been used for transfection of A549 cells without affecting cell viability; incubation of liposomes or lipoplexes with human whole blood has no significant effect on neutrophil elastase or β-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility; has been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice

Formal name: (3β)-cholest-5-en-3-ol 3-[N-[2-(dimethylamino)ethyl]carbamate], monohydrochloride

Synonyms:  ​Cholesteryl 3β-N-(dimethylaminoethyl)carbamate

Molecular weight: 537.3

CAS: 166023-21-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cell Biology||Research Area|Lipid Biochemistry|Sterol Lipids

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