A steroidal alkaloid with diverse biological activities; suppresses NF-κB signaling as well as iNOS and COX-2 expression in LPS-stimulated macrophages; inhibits acid sphingomyelinase activity at 10 mM; preferentially blocks replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 µg/ml

Tomatidine (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
6192-62-7
Storage:
-20
UN-No:
Non-Hazardous - /

Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes.{27622} It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM.{26583} It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 µg/ml, respectively).{27624} It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice.{27625} Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.{27623}  

 

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Description

A steroidal alkaloid with diverse biological activities; suppresses NF-κB signaling as well as iNOS and COX-2 expression in LPS-stimulated macrophages; inhibits acid sphingomyelinase activity at 10 mM; preferentially blocks replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 µg/ml, respectively); prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice; has been used as a negative control for cyclopamine in studies involving signaling mediated by the hedgehog pathway

Formal name: (3β,5α,22β,25S)-spirosolan-3-ol, monohydrochloride

Synonyms: 

Molecular weight: 452.1

CAS: 6192-62-7

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases

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