A selective SIP1 agonist (EC50 = 1.35 nM); activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 (EC50 = 46 nM); induces S1P1-dependent lymphopenia in mice

CYM 5442 – 25 mg

Brand:
Cayman
CAS:
1094042-01-9
Storage:
-20
UN-No:
Non-Hazardous - /

Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P1 is important for vascular development and lymphocyte maturation, migration, and trafficking.{24542} CYM 5442 is a full agonist for S1P1 internalization, phosphorylation, and ubiquitination (EC50 = 1.35 nM).{28038} It is ineffective at S1P2, S1P3, S1P4, and S1P5 at concentrations up to 10 µM.{28038} CYM 5442 has been found to activate S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 with an EC50 value of 46 nM.{28038} At 50 nM, CYM 5442 can induce S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 and 85%, respectively.{28038}  

 

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Description

A selective SIP1 agonist (EC50 = 1.35 nM); activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 (EC50 = 46 nM); induces S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 and 85%, respectively, at 50 nM

Formal name: 2-[[4-[5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]amino]-ethanol

Synonyms: 

Molecular weight: 409.5

CAS: 1094042-01-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Vasculature||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity

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