19(R)-Hydroxylated PGs occur in µg/ml concentrations in the semen of certain mammalian species

15(R),19(R)-hydroxy Prostaglandin F2α – 100 µg

Brand:
Cayman
CAS:
1224444-23-8
Storage:
-20
UN-No:
De Minimis - 1170 / 3

19(R)-Hydroxylated prostaglandins (PGs) occur in µg/ml concentrations in the semen of certain mammalian species, especially primates. In the case of humans, the compounds are primarily of the PGE series, and the hydroxyl stereochemistry is 15(S),19(R).{7578} 19(R)-Hydroxylated PGs are also found in the seminal plasma of marsupials, where F-type compounds of the 1 and 2-series predominate.{2390} The 15(R)-hydroxy epimer of these 19-hydroxylated PGs is the inverse or “unnatural” isomer at C-15. The biological role of 19(R)-hydroxylated PGs is not well established. In the F-series, 19(R)-hydroxylation is associated with a significant loss of receptor-mediated biological activity in some assays.{1441}  

 

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Description

19(R)-Hydroxylated PGs occur in µg/ml concentrations in the semen of certain mammalian species, especially primates. In the case of humans, the compounds are primarily of the PGE series, and the hydroxyl stereochemistry is 15(S),19(R).{7578} 19(R)-Hydroxylated PGs are also found in the seminal plasma of marsupials, where F-type compounds of the 1 and 2-series predominate.{2390} The 15(R)-hydroxy epimer of these 19-hydroxylated PGs is the inverse or “unnatural” isomer at C-15. The biological role of 19(R)-hydroxylated PGs is not well established. In the F-series, 19(R)-hydroxylation is associated with a significant loss of receptor-mediated biological activity in some assays.{1441}

Formal name: 9α,11α,15R,19R-tetrahydroxy-prosta-5Z,13E-dien-1-oic acid

Synonyms:  15(R),19(R)-hydroxy PGF2α

Molecular weight: 370.5

CAS: 1224444-23-8

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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