A potent

GW 441756 – 1 mg

Brand:
Cayman
CAS:
504433-23-2
Storage:
-20
UN-No:
Non-Hazardous - /

The high affinity nerve growth factor (NGF) receptor, also known as NGF tyrosine kinase receptor A (TrkA), is involved in the development and maturation of the nervous system. Aberrant expression is associated with certain forms of cancer and congenital insensitivity to pain with anhidrosis.{27678,27676} GW 441756 is a potent inhibitor of TrkA (IC50 = 2 nM).{27675} It displays >100-fold selectivity over a panel of related kinases.{27675} GW 441756 has been used to clarify the role of TrkA in regulating gene expression in neuroblastoma cells and, more recently, in amyloid-β protein precursor cleavage in neuroglioma cells.{27677,27674}  

 

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Description

A potent, selective inhibitor of TrkA (IC50 = 2 nM); used to clarify the role of TrkA in regulating cell function

Formal name: 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one

Synonyms: 

Molecular weight: 275.3

CAS: 504433-23-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Neuroscience

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