A potent

BRL 50481 – 25 mg

Brand:
Cayman
CAS:
433695-36-4
Storage:
-20
UN-No:
Non-Hazardous - /

BRL 50481 is a potent, selective inhibitor of phosphodiesterase (PDE) 7, inhibiting human recombinant PDE7A1 with a Ki value of 180 nM.{27633} It is much less effective against PDE3 and PDE4 and is without effect against PDE1B, PDE1C, PDE2, and PDE5.{27633} Through its effects on PDE7A1, BRL 50481 enhances the inhibitory effects of the PDE4 blocker rolipram (Item No. 10011132) on monocytes, lung macrophages, and CD8+ T-lymphocytes.{27633} BRL 50481, at 30 µM, promotes apoptosis in chronic lymphocytic leukemia cells overexpressing PDE7B, suggesting that this compound also acts against PDE7B.{27635} BRL 50481 can be used to evaluate the role of PDE7 isoforms in intracellular signaling.{27634}  

 

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Description

A potent, selective inhibitor of PDE7, inhibiting human recombinant PDE7A1 with a Ki value of 180 nM; enhances the inhibitory effects of the PDE4 blocker rolipram on monocytes, lung macrophgaes, and CD8+ T-lymphocytes; promotes apoptosis in chronic lymphocytic leukemia cells overexpressing PDE7B

Formal name: N,N,2-trimethyl-5-nitro-benzenesulfonamide

Synonyms: 

Molecular weight: 244.3

CAS: 433695-36-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity

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