A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma.{8941

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α – 10 mg

Brand:
Cayman
CAS:
294856-01-2
Storage:
-20
UN-No:
De Minimis - 1231 / 3

A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.{9736} 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α would act very much like the free acid of latanoprost.  

 

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A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.{9736} 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α would act very much like the free acid of latanoprost.

Formal name: 9α,11α,15R-trihydroxy-17-(3-(trifluoromethyl)phenyl)-18,19,20-trinor-prosta-5Z-en-1-oic acid

Synonyms:  17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α

Molecular weight: 458.5

CAS: 294856-01-2

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology

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