A potent

Nexturastat A – 1 mg

Brand:
Cayman
CAS:
1403783-31-2
Storage:
-20
UN-No:
Non-Hazardous - /

Nexturastat A is a potent inhibitor of HDAC6 (IC50 = 5.02 nM) that displays high selectivity over all other HDACs.{29222} It dose-dependently induces hyperacetylation of α-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation.{29222} Nexturastat A is cell-permeable and inhibits the proliferation of B16 cells (GI50 = 14.3 µM).{29222}  

 

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Description

A potent, selective inhibitor of HDAC6 (IC50 = 5.02 nM); dose-dependently induces hyperacetylation of α-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation

Formal name: 4-​[[butyl[(phenylamino​)​carbonyl]​amino]​methyl]​-​N-​hydroxy-benzamide

Synonyms: 

Molecular weight: 341.4

CAS: 1403783-31-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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