An indolizidine alkaloid naturally found in certain plants that inhibits N-linked glycoside hydrolases

Swainsonine – 1 mg

Brand:
Cayman
CAS:
72741-87-8
Storage:
-20
UN-No:
Non-Hazardous - /

Swainsonine is an indolizidine alkaloid naturally found in certain plants including locoweed that inhibits N-linked glycoside hydrolases, preventing the processing of asparagine-linked glycoproteins. It reversibly inhibits lysosomal α-mannosidase and Golgi α-mannosidase II (IC50 = 0.2 μM).{17179} Swainsonine is used to study the role of N-linked glycosylation in cellular processes and has been shown to have antiproliferative and antimetastatic effects on cancer cells in culture and in mice.{17180,17181,17182} The inhibition of α-mannosidase activity in lysosomes produces an accumulation of partially-processed oligosaccharides and glycoproteins, giving rise to lysosomal storage disease. Swainsonine toxicity in herbivores results in a condition known as locoism, characterized by hyperactivity, aggression, stiff and clumsy gait, low head carriage, salivation, seizures, and apparent blindness, culminating in increased miscoordination, weakness and death.  

 

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Description

An indolizidine alkaloid naturally found in certain plants that inhibits N-linked glycoside hydrolases, preventing the processing of asparagine-linked glycoproteins; reversibly inhibits lysosomal α-mannosidase and Golgi α-mannosidase II (IC50 = 0.2 μM); shown to have antiproliferative and antimetastatic effects on cancer cells in culture and in mice

Formal name: (1S,2R,8aR)-octahydro-indolizinetriol

Synonyms:  Tridolgosir

Molecular weight: 173.2

CAS: 72741-87-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases

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