A prostacyclin analog that is orally active with prolonged availability in vivo

Cicaprost – 5 mg

Brand:
Cayman
CAS:
94079-80-8
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Prostaglandin I2 (PGI2, prostacyclin) is the most potent endogenous vasodilator that affects both the systemic and pulmonary circulation.{643} Cicaprost is a PGI2 analog that is orally active with prolonged availability in vivo, having a terminal half life in plasma of one hour.{6640}{18554} In addition to their effects on smooth muscle, PGI2 analogs, including cicaprost, have been shown to inhibit the pro-inflammatory actions of certain leukocytes, suppress cardiac fibrosis, and block mitogenesis of certain cell types.{18547}{18548}{18546} Importantly, cicaprost has been shown to strongly reduce lung and lymph node metastasis in rats, suggesting that it might be useful in cancer therapy.{19177}  

 

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Description

A prostacyclin analog that is orally active with prolonged availability in vivo, having a terminal half-life in plasma of one hour; inhibits the pro-inflammatory actions of certain leukocytes, suppresses cardiac fibrosis, and blocks mitogenesis of certain cell types

Formal name: 2-[2-[(2E,3aS,4S,5R,6aS)-hexahydro-5-hydroxy-4-[(3S,4S)-3-hydroxy-4-methyl-1,6-nonadiyn-1-yl]-2(1H)-pentalenylidene]ethoxy]-acetic acid

Synonyms:  ZK 96480

Molecular weight: 374.5

CAS: 94079-80-8

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Heart||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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