A potential metabolite of latanoprost when administered to animals; common minor impurity found in commercial preparations of the bulk drug compound

15-keto Latanoprost (free acid) – 10 mg

Brand:
Cayman
CAS:
369585-22-8
Storage:
-20
UN-No:
De Minimis - 1231 / 3

15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye.{1107} 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type prostaglandins; for example, prostaglandin F2α will produce this degree of miosis at a dose of less than 1 µg/eye.{1107}  

 

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Description

A potential metabolite of latanoprost when administered to animals; common minor impurity found in commercial preparations of the bulk drug compound

Formal name: 9α,11α-dihydroxy-15-oxo-17-phenyl-18,19,20-trinor-prost-5Z-en-1-oic acid

Synonyms: 

Molecular weight: 388.5

CAS: 369585-22-8

Purity: ≥95%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Pharmaceutical Impurities||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology

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