An isomer of 17-phenyl trinor PGF2α

15(R)-17-phenyl trinor Prostaglandin F2α – 5 mg

Brand:
Cayman
CAS:
41639-71-8
Storage:
-20
UN-No:
De Minimis - 1231 / 3

17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide.{8941} Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 µg/cornea/24 hours.{9311} The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.{2058,1374} 15(R)-17-phenyl trinor PGF2α is the 15-epi, or “unnatural” isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer.{9736} In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.  

 

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Description

An isomer of 17-phenyl trinor PGF2α, characterized by an inverted (β) hydroxyl group at C-15

Formal name: 9α,11α,15R-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid

Synonyms:  15(R)-17-phenyl trinor PGF2α|15(R)-Bimatoprost (free acid)|15-epi Bimatoprost (free acid)

Molecular weight: 388.5

CAS: 41639-71-8

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology

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