A metabolically stable analog of PGF2α and potent FP receptor agonist (Ki = 1.1 nM at the rat FP receptor)

17-phenyl trinor Prostaglandin F2α – 5 mg

Brand:
Cayman
CAS:
38344-08-0
Storage:
-20
UN-No:
Non-Hazardous - /

17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α.{2058} At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF2α binding with a Ki of 1.1 nM.{1374} The isopropyl ester of 17-phenyl trinor PGF2α ethyl amide is slightly better than PGF2α isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.{1107}  

 

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Description

A metabolically stable analog of PGF2α and potent FP receptor agonist (Ki = 1.1 nM at the rat FP receptor)

Formal name: 9α,11α,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid

Synonyms:  17-phenyl trinor PGF2α|Bimatoprost (free acid)

Molecular weight: 388.5

CAS: 38344-08-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology

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