An enantiomer of ibuprofen that does not inhibit COX; inhibits NF-κB activation (IC50 = 121.8 µM) in response to T-cell stimulation; blocks superoxide formation

(R)-Ibuprofen – 100 mg

Brand:
Cayman
CAS:
51146-57-7
Storage:
-20
UN-No:
Non-Hazardous - /

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53 µM, respectively).{1286} It is commonly synthesized as a racemic mixture of (S) and (R) isomers (Item No. item 70280). (R)-Ibuprofen is an enantiomer that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids.{27416} The (R) enantiomer can, however, inhibit NF-κB activation (IC50 = 121.8 µM) in response to T-cell stimulation as well as block superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 40-100 µM).{6935,27418} 50-60% of (R)-ibuprofen is inverted to (S)-ibuprofen (Item No. 16793) in humans after oral administration.{27416,27417,10032}  

 

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Description

An enantiomer of ibuprofen that does not inhibit COX; inhibits NF-κB activation (IC50 = 121.8 µM) in response to T-cell stimulation; blocks superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50s = 40-100 µM); can be inverted to (S)-ibuprofen in humans after oral administration

Formal name: α-methyl-4-(2-methylpropyl)-(αR)-benzeneacetic acid

Synonyms:  (-)-Ibuprofen

Molecular weight: 206.3

CAS: 51146-57-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Lipid Biochemistry|Glycerolipids||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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