A dual agonist of PPARα and γ (IC50s = 1 and 0.2 µM

Tesaglitazar – 5 mg

Brand:
Cayman
CAS:
251565-85-2
Storage:
-20
UN-No:
Non-Hazardous - /

Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPARα demonstrates a particular role in fatty acid oxidation whereas PPARγ is known to be involved in adipocyte differentiation and lipid storage. Tesaglitazar, a dihydro cinnamate derivative, is a dual agonist of PPARα and γ that demonstrates IC50 values of 1 and 0.2 µM, respectively in ligand binding assays.{27507} At 3 µM/kg/day for three weeks, tesaglitazar has been used to reduce insulin resistance in obese Zucker rats.{27508} Furthermore, it has been investigated clinically for its potential to address disorders in glucose and lipid metabolism in patients with type 2 diabetes.{27509}  

 

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Description

A dual agonist of PPARα and γ (IC50s = 1 and 0.2 µM, respectively) that at 3 µM/kg/day for 3 weeks has been used to reduce insulin resistance in obese Zucker rats

Formal name: (αS)-ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]-benzenepropanoic acid

Synonyms:  AZ 242|GalidaTM

Molecular weight: 408.5

CAS: 251565-85-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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