A synthetic analog of PGF2α; an FP receptor agonist and a potent luteolytic agent in rats and hamsters; the optically active

(+)-Cloprostenol – 10 mg

Brand:
Cayman
CAS:
54276-21-0
Storage:
-20
UN-No:
De Minimis - 1170 / 3

(+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. It is 200 times more potent than PGF2α in terminating pregnancy when given subcutaneously at a daily dose of 0.125 μg/kg in rats and hamsters, without the side effects associated with PGF2α.{1182} (+)-Cloprostenol was also shown to be a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 value of 3 pM.{4404}  

 

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Description

A synthetic analog of PGF2α; an FP receptor agonist and a potent luteolytic agent in rats and hamsters; the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity

Formal name: (+)-9α,11α,15R-trihydroxy-16-(3-chlorophenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid

Synonyms:  (+)-16-m-chlorophenoxy tetranor PGF2α|(+)-16-m-chlorophenoxy tetranor Prostaglandin F2α|D-Cloprostenol

Molecular weight: 424.9

CAS: 54276-21-0

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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