A natural non-selective phytotoxin that is converted in vivo to the active agent phosphinothricin

Bialaphos (sodium salt) – 10 mg

Brand:
Cayman
CAS:
71048-99-2
Storage:
-20
UN-No:
Non-Hazardous - /

Bialaphos is a natural non-selective phytotoxin produced by certain Streptomyces species. It is a pro-toxin, a tripeptide that is converted in vivo to the active agent phosphinothricin, which is a glutamine analog.{27463} L-Phosphinothricin inhibits glutamine synthetase (Ki = 6.1 µM), resulting in accumulation of ammonium and disruption of primary metabolism.{27463,27464} The bacterial bar gene encodes a phosphinothricin acetyltransferase, which confers resistance to phosphinothricin.{27244} Bialaphos is used in the selection of transgenic plants that express the bar gene, usually under the control of a constitutively active viral promoter.{27244}  

 

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Description

A natural non-selective phytotoxin that is converted in vivo to the active agent phosphinothricin, which inhibits glutamine synthetase (Ki = 6.1 µM); used in the selection of transgenic plants that express the bar gene, usually under the control of a constitutively active viral promoter

Formal name: 2S-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine, monosodium salt

Synonyms:  SF 1293

Molecular weight: 345.3

CAS: 71048-99-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Toxins||Research Area|Plant Biology|Phytotoxins

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