3,3′-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3’-T2.{27332} It is derived enzymatically from triiodothyronine isoforms T3 and reverse T3. T2 and its analog 3,5-T2 stimulate the activity of cytochrome c oxidase by blocking inhibition by ATP.{27333,27334}
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A metabolite of thyroid hormone
Formal name: O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
Synonyms: 3,3′-T2|L-3,3′-Diiodothyronine|T2
Molecular weight: 525.1
CAS: 4604-41-5
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones
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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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