An inhibitor of JAK3 (IC50 = 79 nM); also inhibits the transglutaminases TGM2 and Factor XIIIa (IC50s= 10 and 25 nM

ZM 39923 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
1021868-92-7
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription (Stat) family.{20362} ZM 39923 is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 µM, respectively).{27341} In the absence of the reducing agent dithiothreitol, ZM 39923 also inhibits human tissue transglutaminase 2 (TGM2) and the transglutaminase Factor XIIIa (IC50s= 10 and 25 nM, respectively).{22726} It breaks down in neutral buffer to form ZM 449829, which is also an inhibitor of JAK3, TGM2, and Factor XIIIa.{27341,22726}  

 

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Description

An inhibitor of JAK3 (IC50 = 79 nM); also inhibits the transglutaminases TGM2 and Factor XIIIa (IC50s= 10 and 25 nM, respectively) in the absence of dithiothreitol; breaks down in neutral buffer to form ZM 449829

Formal name: 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-1-propanone, monohydrochloride

Synonyms:  JAK3 Inhibitor IV

Molecular weight: 367.9

CAS: 1021868-92-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|JAK Family||Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|JAK Signaling

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