A β1 adrenergic receptor antagonist and a β2 adrenergic receptor partial agonist that relaxes human arteries and veins with ED50 values of 40-50 µM in vitro; reduces myocardial infarct size and increases NO production in a rabbit model of myocardial ischemia at 1-10 mg/kg/h

Celiprolol (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
57470-78-7
Storage:
-20
UN-No:
Non-Hazardous - /

Celiprolol is a β1 adrenergic receptor antagonist and a β2 adrenergic receptor partial agonist that has been shown to relax human arteries and veins with ED50 values of 40-50 µM in vitro.{27275} At 1-10 mg/kg/h, celiprolol can reduce myocardial infarct size and increase nitric oxide (NO) production in a rabbit model of myocardial ischemia.{27273} Furthermore, 100 mg/kg/d celiprolol has been reported to stimulate expression and activate phosphorylation of endothelial NO synthase in rat cardiac myocytes.{27274}  

 

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Description

A β1 adrenergic receptor antagonist and a β2 adrenergic receptor partial agonist that relaxes human arteries and veins with ED50 values of 40-50 µM in vitro; reduces myocardial infarct size and increases NO production in a rabbit model of myocardial ischemia at 1-10 mg/kg/h

Formal name: N’-​​[3-​​acetyl-​​4-​​[3-​​[(1,​1-​​dimethylethyl)​amino]-​2-​​hydroxypropoxy]​phenyl]​-​​N,​N-​diethyl-​urea, monohydrochloride

Synonyms:  Corliprol|NSC 324509

Molecular weight: 416

CAS: 57470-78-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart|Arrhythmia

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