A potent inhibitor of the kinase activity of ALK2 (IC50 = 13-108 nM); disrupts dorsoventral development in zebrafish; affects stem cell development

DMH1 – 50 mg

Brand:
Cayman
CAS:
1206711-16-1
Storage:
-20
UN-No:
De Minimis - 2811 / 3

Bone morphogenetic proteins (BMP) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation.{23503} DMH1 is an analog of the non-selective BMP receptor inhibitor dorsomorphin (Item No. 11967) that potently inhibits the kinase activity of activin receptor-like kinase 2 (ALK2; IC50 = 13-108 nM).{28912,28826} It is much less effective at ALK4, ALK5, AMPK, KDR (VEGFR2) or PDGFRβ, although it inhibits ALK1 and ALK3 at nanomolar concentrations.{28912,28826} DMH1 is effective in vivo, as it disrupts dorsoventral development in zebrafish.{28912} It also affects stem cell development, increasing cardiomyocyte progenitors and promoting neurogenesis.{28911,28914} DMH1 inhibits the growth of lung cancer cells, reducing tumor growth in a xenograft mouse model.{28913}  

 

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Description

A potent inhibitor of the kinase activity of ALK2 (IC50 = 13-108 nM); disrupts dorsoventral development in zebrafish; affects stem cell development, increasing cardiomyocyte progenitors and promoting neurogenesis; inhibits the growth of lung cancer cells, reducing tumor growth in a xenograft model

Formal name: 4-[6-[4-(1-methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline

Synonyms:  BMP Inhibitor II|DorsoMorphin Homolog 1|VU036482

Molecular weight: 380.4

CAS: 1206711-16-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Activin-like Kinases (ALKs)||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ALK (Activin-like Kinase) Signaling||Research Area|Cell Biology|Cell Signaling||Research Area|Cell Biology|Stem Cell Research||Research Area|Neuroscience

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