A natural 11-membered macrocyclic pyrrolizidine alkaloid used in an animal model of pulmonary hypertension

Monocrotaline – 500 mg

Brand:
Cayman
CAS:
315-22-0
Storage:
-20
UN-No:
De Minimis - 1544 / 6.1

Monocrotaline is a natural 11-membered macrocyclic pyrrolizidine alkaloid used in an animal model of pulmonary hypertension.{27325,27324} It is metabolized by cytochrome P450 3A4 in the liver to monocrotaline pyrrole. Administration of monocrotaline or its metabolite monocrotaline pyrrole to rats causes progressive lung injury featuring pulmonary vascular remodeling, pulmonary hypertension, and compensatory right heart hypertrophy.{27325,27324}  

 

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Description

A natural 11-membered macrocyclic pyrrolizidine alkaloid used in an animal model of pulmonary hypertension

Formal name: (3R,4R,5R)-4,5,8,10,12,13,13aR,13bR-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione

Synonyms:  Crotaline|MCT|NSC 28693

Molecular weight: 325.4

CAS: 315-22-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension

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