A DNA alkylating agents that induces DNA interstrand and intrastrand crosslinks

Melphalan – 100 mg

Brand:
Cayman
CAS:
148-82-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Melphalan is a phenylalanine derivative of mechlorethamine, belonging to the family of nitrogen mustard alkylating agents that are used for chemotherapy.{26270} It attaches an alkyl group to guanine bases in DNA at the 7-nitrogen of the imidazole ring, which leads to DNA interstrand and intrastrand crosslinks, cytotoxicity, and apoptosis.{26270} Melphalan can inhibit the growth of PC-3 prostate cancer cells with IC50 values of 0.074 or 0.77 μM for sequential dosing or single dosing, respectively.{27295}  

 

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Description

A DNA alkylating agents that induces DNA interstrand and intrastrand crosslinks, cytotoxicity, and apoptosis; inhibits the growth of PC-3 prostate cancer cells with IC50 values of 0.074 or 0.77 μM for sequential dosing or single dosing, respectively

Formal name: 4-​[bis(2-​chloroethyl)​amino]​-L-​phenylalanine

Synonyms:  Alanine Nitrogen Mustard|Alkeran|L-Phenylalanine Mustard|NSC 241286|NSC 8806

Molecular weight: 305.2

CAS: 148-82-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|DNA Alkylating Agents||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair|DNA Alkylating Agents

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