An antagonist/partial agonist of the androgen receptor (IC50 = 26 nM in humans) that has been shown to have clinical use in androgen-dependent conditions such as prostate cancer

Cyproterone Acetate – 250 mg

Brand:
Cayman
CAS:
427-51-0
Storage:
-20
UN-No:
Non-Hazardous - /

Cyproterone acetate (CPA) is a synthetic steroid that acts as an antagonist/partial agonist of the androgen receptor (IC50 = 26 nM in humans).{27128} Androgen receptor antagonists such as CPA have been shown to have clinical use in androgen-dependent conditions such as prostate cancer, hirsutism, and alopecia.{27128,27129} However, high doses of CPA (10 mg/animal/day) can suppress accessory sexual glands and fertility in adult male rats.{27132} CPA promotes hepatomitogenic activity and has been reported to induce apoptosis of hepatocytes in rats at 0.3 µM after 72 hours exposure.{27131,27130}  

 

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Description

An antagonist/partial agonist of the androgen receptor (IC50 = 26 nM in humans) that has been shown to have clinical use in androgen-dependent conditions such as prostate cancer, hirsutism, and alopecia; suppresses accessory sexual glands and fertility in adult male rats (10 mg/animal/day); induces apoptosis of hepatocytes in rats at 0.3 µM after 72 hours exposure

Formal name: (1β,2β)-17-acetyloxy-6-chloro-1,2-dihydro-3’H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione

Synonyms:  Androcur®|CPA|Cyprostat|NSC 81430|SH 714

Molecular weight: 416.9

CAS: 427-51-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Androgens||Research Area|Endocrinology & Metabolism|Reproductive Biology

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