A sodium channel blocker and local anesthetic; inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner; increases the firing threshold in rat sympathetic ganglia at 200 nM; blocks cardiac sodium channels in a use-dependent manner at 10 µM; inhibits respiration in cardiac cell mitochondria when palmitoyl-carnitine or acetyl-carnitine are used as substrates (IC50s = 0.78 and 0.37 mM

Bupivacaine – 5 g

Brand:
Cayman
CAS:
38396-39-3
Storage:
-20
UN-No:
Limited Quantity - 2811 / 6.1

Bupivacaine is a sodium channel blocker and local anesthetic.{49026,49029} It inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner and inhibits synaptic transmission in rat sympathetic ganglia, increasing the firing threshold when used at a concentration of 200 nM.{49030,49027} Bupivacaine (10 µM) blocks cardiac sodium channels in a use-dependent manner and inhibits respiration in cardiac cell mitochondria when palmitoyl-carnitine or acetyl-carnitine are used as substrates (IC50s = 0.78 and 0.37 mM, respectively).{49026,49028} It also reduces thermal hyperplasia in a rat model of sciatic ligation injury when 0.6 ml of a 0.5% solution is administered into the perinerve space, and the duration of this effect is extended by co-administration of the NMDA receptor antagonist MK-801 (Item No. 10009019).{49029} Formulations containing bupivacaine have been used as local anesthetics for surgery, oral surgery, and dental procedures and for anesthetic purposes in research studies using animals.  

 

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Description

A sodium channel blocker and local anesthetic; inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner; increases the firing threshold in rat sympathetic ganglia at 200 nM; blocks cardiac sodium channels in a use-dependent manner at 10 µM; inhibits respiration in cardiac cell mitochondria when palmitoyl-carnitine or acetyl-carnitine are used as substrates (IC50s = 0.78 and 0.37 mM, respectively); reduces thermal hyperplasia in a rat model of sciatic ligation injury when 0.6 ml of a 0.5% solution is administered into the perinerve space

Formal name: 1-butyl-​N-(2,​6-​dimethylphenyl)-2-​piperidinecarboxamid​e

Synonyms: 

Molecular weight: 288.4

CAS: 38396-39-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Pain Research

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