A mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases

BIBR 1532 – 50 mg

Brand:
Cayman
CAS:
321674-73-1
Storage:
-20
UN-No:
Non-Hazardous - /

BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase.{27220,27216,27218} It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT.{27216,27217} Through its effects on telomerase, BIBR 1532 induces senescence or apoptosis in cancer cells.{27220,27219} Apoptosis in triple negative breast cancer cells induced by BIBR 1532 is potentiated by glucose restriction.{27219}  

 

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Description

A mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase; induces senescence or apoptosis in cancer cells

Formal name: 2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-buten-1-yl]amino]-benzoic acid

Synonyms:  Telomerase Inhibitor X

Molecular weight: 331.4

CAS: 321674-73-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Metabolism

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