An M4 mAChR antagonist (pKi = 7.2 in chicken heart) that produces temporary mydriasis (pupil dilation; EC50 = 6 µg/ml) and cycloplegia (ciliary muscle paralysis; EC50 = 25 µg/ml) when applied as eye drops; used to probe mAChR activity in a mouse model of fragile X syndrome

Tropicamide – 1 g

Brand:
Cayman
CAS:
1508-75-4
Storage:
-20
UN-No:
Non-Hazardous - /

Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially couple to various effector systems based on their G protein interaction.{27107,27108}Tropicamide is a muscarinic acetylcholine receptor (mAChR) antagonist (pKi = 7.2 in chicken heart) that displays 3-fold selectivity for M4.{27107,27106,27105} When applied as eye drops, it produces temporary mydriasis (pupil dilation; EC50 = 6 µg/ml) and cycloplegia (ciliary muscle paralysis; EC50 = 25 µg/ml).{27109} Tropicamide has been used to probe mAChR activity in a mouse model of fragile X syndrome.{27110}  

 

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Description

An M4 mAChR antagonist (pKi = 7.2 in chicken heart) that produces temporary mydriasis (pupil dilation; EC50 = 6 µg/ml) and cycloplegia (ciliary muscle paralysis; EC50 = 25 µg/ml) when applied as eye drops; used to probe mAChR activity in a mouse model of fragile X syndrome

Formal name: N​-​ethyl​-α​-​(hydroxymethyl)​-​N​-​(4​-​pyridinylmethyl)​-benzeneacetamide

Synonyms:  Ro 1-7683

Molecular weight: 284.4

CAS: 1508-75-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Ophthalmology

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