A primary metabolite of nicotinamide produced by the action of NNMT; demonstrates antithrombotic and anti-inflammatory properties and may play a role in cancer cell metabolism

1-Methylnicotinamide (chloride) – 1 g

Brand:
Cayman
CAS:
1005-24-9
Storage:
-20
UN-No:
Non-Hazardous - /

Nicotinamide is a precursor of NAD (Item No. 16077) and NADP (Item No. 10004675), which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; Item No. 15138).{24617} It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability.{24618,27798} Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.{24772,24614}  

 

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Description

A primary metabolite of nicotinamide produced by the action of NNMT; demonstrates antithrombotic and anti-inflammatory properties and may play a role in cancer cell metabolism

Formal name: 3-(aminocarbonyl)-1-methyl-pyridinium, monochloride

Synonyms:  N1-Methylnicotinamide chloride|Nicotinamide methochloride|Trigonellamide chloride

Molecular weight: 172.6

CAS: 1005-24-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Immunology & Inflammation

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