A very potent inhibitor of sEH (IC50 = 0.5 nM); displays high oral bioavailability for doses ranging from 0.01 to 1 mg/kg; with the COX-2 inhibitor celecoxib

trans-AUCB – 50 mg

Brand:
Cayman
CAS:
885012-33-9
Storage:
-20
UN-No:
Non-Hazardous - /

Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects.{14072,12607} trans-AUCB is a very potent inhibitor of sEH (IC50 = 0.5 nM).{19484} It displays high oral bioavailability for doses ranging from 0.01 to 1 mg/kg.{20116,17571} Dual inhibition of COX-2 and sEH, by celecoxib (Item No. 10008672) and trans-AUCB, suppresses tumor angiogenesis, inhibiting tumor growth and metastasis in a Lewis lung carcinoma model in mice.{26684}  

 

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Description

A very potent inhibitor of sEH (IC50 = 0.5 nM); displays high oral bioavailability for doses ranging from 0.01 to 1 mg/kg; with the COX-2 inhibitor celecoxib, suppresses tumor angiogenesis, inhibiting tumor growth and metastasis in a Lewis lung carcinoma model in mice

Formal name: 4-[[trans-4-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]cyclohexyl]oxy]-benzoic acid

Synonyms: 

Molecular weight: 412.5

CAS: 885012-33-9

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Migration & Metastasis

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