Key urinary metabolite of PGD2; represents approximately 1% and 4% of the infused radiolabeled dose in monkeys and humans

2,3-dinor-11β-Prostaglandin F2α – 25 µg

Brand:
Cayman
CAS:
240405-20-3
Storage:
-20
UN-No:
De Minimis - 1170 / 3

2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where it represented approximately 1% and 4% of the infused radiolabeled dose, respectively.{418} 2,3-dinor-11β-PGF2α has also been recovered from the urine of mastocytosis patients, where it is excreted in large amounts.{416} In human asthmatic patients, 2,3-dinor-11β-PGF2α represents about 40% (as determined by GC/MS) of the immunoreactive 11β-PGF2α when measured using Cayman’s 11β-PGF2α EIA Kit (Item No. 516521). The excretion rate for 2,3-dinor-11β-PGF2α is approximately 200-250 ng/24 hours in a normal adult.{7577}  

 

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Description

Key urinary metabolite of PGD2; represents approximately 1% and 4% of the infused radiolabeled dose in monkeys and humans, respectively

Formal name: 9α,11β,15S-trihydroxy-2,3-dinor-prosta-5Z,13E-dien-1-oic acid

Synonyms:  2,3-dinor-11-epi PGF2α|2,3-dinor-11β-PGF2α

Molecular weight: 326.4

CAS: 240405-20-3

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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