A naturally-occurring macrocyclic lactone that is a potent insecticide; acts as an agonist of insect nicotinic acetylcholinesterase receptors (nAChRs)

Spinosyn A – 5 mg

Brand:
Cayman
CAS:
131929-60-7
Storage:
-20
UN-No:
Non-Hazardous - /

Spinosyn A is a naturally-occurring macrocyclic lactone that is a potent insecticide.{26992,26993} It acts as an agonist of insect nicotinic acetylcholinesterase receptors (nAChRs), which differ both structurally and functionally from nAChRs in vertebrates.{26995} As a result, it has low affinity for vertebrate nAChRs and has limited adverse effects in those animals.{26995,26996} Spinosyn A is produced naturally by the fermentation of the bacterium S. spinosa and its chemical synthesis has been described.{26994}  

 

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Description

A naturally-occurring macrocyclic lactone that is a potent insecticide; acts as an agonist of insect nicotinic acetylcholinesterase receptors (nAChRs), which differ both structurally and functionally from nAChRs in vertebrates

Formal name: (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-2-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-1H-as-indaceno[3,2-d]oxacyclododecin-7,15-dione

Synonyms:  A-83543A|Lepicidin A

Molecular weight: 732

CAS: 131929-60-7

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Pesticides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology

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