The primary PGD2 metabolite; formed from PGD2 via PGFS in the liver or lung; induces contraction of isolated cat iris sphincter (EC50 = 0.045 µM); induces contraction of isolated human bronchial smooth muscle from 0.1-30 µM; induces ERK and CREB phosphorylation

11β-Prostaglandin F2α – 5 mg

Brand:
Cayman
CAS:
38432-87-0
Storage:
-20
UN-No:
Non-Hazardous - /

11β-Prostaglandin F2α (11β-PGF2α) is the primary metabolite of PGD2 (Item No. 12010).{57057} It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase (PGFS; Item No. 10007940) in the liver or lung.{57058} 11β-PGF2α induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF2α (FP) receptors, with an EC50 value of 0.045 µM.{57057} It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 µM.{1756} 11β-PGF2α (0.1 and 1 µM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 µM.{57059}  

 

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Description

The primary PGD2 metabolite; formed from PGD2 via PGFS in the liver or lung; induces contraction of isolated cat iris sphincter (EC50 = 0.045 µM); induces contraction of isolated human bronchial smooth muscle from 0.1-30 µM; induces ERK and CREB phosphorylation, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor at 0.1 and 1 µM

Formal name: (5Z,9α,11β,13E,15S)-9,11,15-trihydroxy-prosta-5,13-dien-1-oic acid

Synonyms:  11-epi PGF2α|11β-PGF2α|9α,11β-PGF2α

Molecular weight: 354.5

CAS: 38432-87-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology

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