A selective RORα and RORγ agonist that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 µM without effect at the related LXR and FXR receptors; stabilizes p53 and induces apoptosis in HepG2 cancer cells

SR 1078 – 5 mg

Brand:
Cayman
CAS:
1246525-60-9
Storage:
-20
UN-No:
Non-Hazardous - /

Retinoic acid receptor-related orphan receptors α and γ (RORα and RORγ) have been demonstrated to play important roles in the regulation of metabolism, circadian rhythms, immune function, and tumorigenesis. SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 µM without effect at the related liver X receptors and farnesoid X receptors.{26889} At 5 µM, SR 1078 has been shown to stabilize p53 and to induce apoptosis in HepG2 cancer cells.{26890}  

 

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Description

A selective RORα and RORγ agonist that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 µM without effect at the related LXR and FXR receptors; stabilizes p53 and induces apoptosis in HepG2 cancer cells

Formal name: N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)-benzamide

Synonyms: 

Molecular weight: 431.3

CAS: 1246525-60-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs

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